Journal of Heterocyclic Chemistry

Functionalization of Quinazolin??4??ones Part 1: Synthesis of Novel 7??Substituted??2??thioxo Quinazolin??4??ones from 4??Substituted??2??Aminobenzoic Acids and PPh3 ( …

J Heppell, J Al??Rawi

文献索引：Heppell, Jacob; Al-Rawi, Jasim Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 1 p. 162 - 174

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被引用次数: 8

摘要

Abstract 4-(Nitro, amino, acetylamino)-2-aminobenzoic acid were allowed to react with PPh 3 (SCN) 2 and gave the crossholding 7-nitro, 7-acetylamino-and 7-amino-2-thioxo quinazolin-4-ones respectively. The nature of the substituent at position 4 of the 2- aminobenzoic acids has significant influence on the outcome of the cyclisation reaction with PPh 3 (SCN) 2. Similarly, the nature of the substituent at position 7 of the 2-substituted ...