Tetrahedron letters

Selective N-alkylation of pyrrolopyrimidines and indoles by “transfer of activation”

SB Sobolov, J Sun, BA Cooper

文献索引：Sobolov, Susan B.; Sun, Jianmin; Cooper, Beth A. Tetrahedron Letters, 1998 , vol. 39, # 32 p. 5685 - 5688

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被引用次数: 15

摘要

The benzene sulfonyl group is used as a “transfer of activation” reagent to alkylate selectively the NH of both pyrrolopyrimidines and 5-aminoindoles substituted on thienopyrimidines. A variety of primary and secondary alcohols are utilized as alkylating substrates.