Facile synthesis of new imidazo [1, 2-a] pyridines carrying 1, 2, 3-triazoles via click chemistry and their antiepileptic studies

S Ulloora, R Shabaraya, AV Adhikari

文献索引：Ulloora, Shrikanth; Shabaraya, Ramakrishna; Adhikari, Airody Vasudeva Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3368 - 3372

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被引用次数: 23

摘要

The present article reports the synthesis and anticonvulsant studies of new 2-arylimidazo [1, 2-a] pyridines carrying suitably substituted 1, 2, 3-triazoles as well as their intermediates. The structures of newly synthesized compounds were confirmed by various spectroscopic techniques. The anticonvulsant study was carried out by MES and scPTZ screening methods, while their toxicity study was performed following Rotarod method. The active ...