Synthesis of Medium and Large Cyclic Amines in Rhodium-Catalysed Reactions of Aminoalkenes with H2/CO

DJ Bergmann, EM Campi, WR Jackson, AF Patti…

文献索引：Bergmann, David J.; Campi, Eva M.; Roy Jackson; Patti, Antonio F.; Saylik, Dilek Australian Journal of Chemistry, 2000 , vol. 53, # 10 p. 835 - 844

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被引用次数: 11

摘要

Abstract Rhodium-catalysed reactions of N-benzyl-or N-alkyl-aminoalkenes (6) with H 2/CO can give cyclic amines (7)(7–13 ring size) in good to excellent yields when BIPHEPHOS is used as a ligand. Hydrogenation of the aminoalkene becomes a competing reaction for the smaller rings but can be overcome by using a H 2/CO gas ratio of 1: 5. Reactions of 2- alkenyloxybenzylamines (13) gave 9-, 12-and 17-membered rings (14) in 30–40% yield, ...