Synthesis and biological activity of a photoaffinity etoposide probe

…, KS Avor, N Barnabé, P Thampatty, JC Yalowich

文献索引：Hasinoff, Brian B.; Chee, Gaik-Lean; Day, Billy W.; Avor, Kwasi S.; Barnabe, Norman; Thampatty, Padmakumari; Yalowich, Jack C. Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 7 p. 1765 - 1771

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被引用次数: 8

摘要

The epipodophyllotoxin etoposide is a potent and widely used anticancer drug that targets DNA topoisomerase II. The synthesis, photochemical, and biological testing of a photoactivatable aromatic azido analogue of etoposide also containing an iodo group is described. This azido analogue should prove useful for identifying the etoposide interaction site on topoisomerase II. Irradiation of the azido analogue and an aldehyde-containing ...