Synthesis and biological activity of a photoaffinity etoposide probe

…, KS Avor, N Barnabé, P Thampatty, JC Yalowich

Index: Hasinoff, Brian B.; Chee, Gaik-Lean; Day, Billy W.; Avor, Kwasi S.; Barnabe, Norman; Thampatty, Padmakumari; Yalowich, Jack C. Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 7 p. 1765 - 1771

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Citation Number: 8

Abstract

The epipodophyllotoxin etoposide is a potent and widely used anticancer drug that targets DNA topoisomerase II. The synthesis, photochemical, and biological testing of a photoactivatable aromatic azido analogue of etoposide also containing an iodo group is described. This azido analogue should prove useful for identifying the etoposide interaction site on topoisomerase II. Irradiation of the azido analogue and an aldehyde-containing ...