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Substituted (2-phenoxyphenyl) acetic acids with antiinflammatory activity. 1

DC Atkinson, KE Godfrey, B Meek…

文献索引:Atkinson, David C.; Godfrey, Keith E.; Meek, Bernard; Saville, John F.; Stillings, Michael R. Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1353 - 1360

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被引用次数: 16

摘要

Method B C0zH pounds investigated at Smith, Kline & French6 are simple derivatives of the plant-growth regulators indole-3-acetic acid, phenylacetic acid, and naphthalene-1-acetic acid respectively. Bearing in mind the already well-known fenamic acid series7 of NSAIDs, we considered that compounds of the general structure shown in Chart I, incorporating a combination of the phenylacetic acid moiety with an extension of the fenamic acid ...

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