e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Substituted (2-phenoxyphenyl) acetic acids with antiinflammatory activity. 1

DC Atkinson, KE Godfrey, B Meek…

Index: Atkinson, David C.; Godfrey, Keith E.; Meek, Bernard; Saville, John F.; Stillings, Michael R. Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1353 - 1360

Full Text: HTML

Citation Number: 16

Abstract

Method B C0zH pounds investigated at Smith, Kline & French6 are simple derivatives of the plant-growth regulators indole-3-acetic acid, phenylacetic acid, and naphthalene-1-acetic acid respectively. Bearing in mind the already well-known fenamic acid series7 of NSAIDs, we considered that compounds of the general structure shown in Chart I, incorporating a combination of the phenylacetic acid moiety with an extension of the fenamic acid ...

Methyl (2-hydroxyphenyl)acetate Structure

Methyl (2-hydro...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

1-Fluoro-2,4-dinitrobenzene Structure

1-Fluoro-2,4-di...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

methyl (2-(2,4-dinitrophenoxy)phenyl)acetate Structure

methyl (2-(2,4-...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

sodium 2,4-dichlorophenolate Structure

sodium 2,4-dich...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

o-Chloroacetophenone Structure

o-Chloroacetophenone

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

Fenclofenac Structure

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

2-(2,4-dichlorophenoxy)benzoic acid Structure

2-(2,4-dichloro...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

2-hydroxybenzaldehyde potassium salt Structure

2-hydroxybenzal...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

2-(2,4-DICHLOROPHENOXY)BENZENECARBALDEHYDE Structure

2-(2,4-DICHLORO...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

(2-(2,4-DICHLOROPHENOXY)PHENYL)METHANOL Structure

(2-(2,4-DICHLOR...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

2,4-dichloro-1-(2-(chloromethyl)phenoxy)benzene Structure

2,4-dichloro-1-...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

2-(2-(2,4-dichlorophenoxy)phenyl)acetamide Structure

2-(2-(2,4-dichl...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

(2-(2,4-dichlorophenoxy)phenyl)acetyl chloride Structure

(2-(2,4-dichlor...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

methyl (2-(2,4-diaminophenoxy)phenyl)acetate Structure

methyl (2-(2,4-...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

2-(2,4-dichlorophenoxy)acetophenone Structure

2-(2,4-dichloro...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

2-Bromobenzaldehyde Structure

2-Bromobenzaldehyde

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

2,4-Dichlorophenol Structure

2,4-Dichlorophenol

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

2-Chlorobenzoic acid Structure

2-Chlorobenzoic acid

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

1,2,4-Trichlorobenzene Structure

1,2,4-Trichloro...

~%

3-[2-(2,4-Dichlorophenoxy)phenyl]propanoic acid Structure

3-[2-(2,4-Dichl...

2'-chloro-5-methylacetophenone Structure

2'-chloro-5-met...

~%

2-(2-Chloro-4-ethylphenoxy)-5-methylbenzeneacetic acid Structure

2-(2-Chloro-4-e...

2-hydroxybenzaldehyde potassium salt Structure

2-hydroxybenzal...

~%

(2-(2,4-DICHLOROPHENOXY)PHENYL)METHANOL Structure

(2-(2,4-DICHLOR...

sodium 2,4-dichlorophenolate Structure

sodium 2,4-dich...

~%

(2-(2,4-DICHLOROPHENOXY)PHENYL)METHANOL Structure

(2-(2,4-DICHLOR...

2-Bromobenzaldehyde Structure

2-Bromobenzaldehyde

~%

(2-(2,4-DICHLOROPHENOXY)PHENYL)METHANOL Structure

(2-(2,4-DICHLOR...

1,2,4-Trichlorobenzene Structure

1,2,4-Trichloro...

~%

(2-(2,4-DICHLOROPHENOXY)PHENYL)METHANOL Structure

(2-(2,4-DICHLOR...

2'-chloro-5-methylacetophenone Structure

2'-chloro-5-met...

~%

2-[2-(4-butan-2-yl-2-chlorophenoxy)-5-methylphenyl]acetic acid Structure

2-[2-(4-butan-2...

Sodium benzenolate Structure

Sodium benzenolate

~%

2-(5-chloro-2-phenoxyphenyl)-1-Morpholinoethanethione Structure

2-(5-chloro-2-p...

morpholine Structure

1-(5-Chloro-2-phenoxyphenyl)ethanone Structure

1-(5-Chloro-2-p...

~%

2-(5-chloro-2-phenoxyphenyl)-1-Morpholinoethanethione Structure

2-(5-chloro-2-p...

2',4'-Dichloroacetophenone Structure

2',4'-Dichloroa...

Sodium benzenolate Structure

Sodium benzenolate

~%

1-(5-Chloro-2-phenoxyphenyl)ethanone Structure

1-(5-Chloro-2-p...

Methyl (2-hydroxyphenyl)acetate Structure

Methyl (2-hydro...

~%

Fenclofenac Structure

1-Fluoro-2,4-dinitrobenzene Structure

1-Fluoro-2,4-di...

~%

Fenclofenac Structure

methyl (2-(2,4-dinitrophenoxy)phenyl)acetate Structure

methyl (2-(2,4-...

~%

Fenclofenac Structure

sodium 2,4-dichlorophenolate Structure

sodium 2,4-dich...

~%

Fenclofenac Structure

2-(2-(2,4-dichlorophenoxy)phenyl)acetamide Structure

2-(2-(2,4-dichl...

~%

Fenclofenac Structure

o-Chloroacetophenone Structure

o-Chloroacetophenone

~%

Fenclofenac Structure

2-(2,4-dichlorophenoxy)benzoic acid Structure

2-(2,4-dichloro...

~%

Fenclofenac Structure

2-hydroxybenzaldehyde potassium salt Structure

2-hydroxybenzal...

~%

Fenclofenac Structure

2-(2,4-DICHLOROPHENOXY)BENZENECARBALDEHYDE Structure

2-(2,4-DICHLORO...

~%

Fenclofenac Structure

(2-(2,4-DICHLOROPHENOXY)PHENYL)METHANOL Structure

(2-(2,4-DICHLOR...

~%

Fenclofenac Structure

2,4-dichloro-1-(2-(chloromethyl)phenoxy)benzene Structure

2,4-dichloro-1-...

~%

Fenclofenac Structure

2-(2,4-dichlorophenoxy)acetophenone Structure

2-(2,4-dichloro...

~%

Fenclofenac Structure

2-Bromobenzaldehyde Structure

2-Bromobenzaldehyde

~%

Fenclofenac Structure

2,4-Dichlorophenol Structure

2,4-Dichlorophenol

~%

Fenclofenac Structure

2-Chlorobenzoic acid Structure

2-Chlorobenzoic acid

~%

Fenclofenac Structure

1,2,4-Trichlorobenzene Structure

1,2,4-Trichloro...

~%

Fenclofenac Structure

methyl (2-(2,4-diaminophenoxy)phenyl)acetate Structure

methyl (2-(2,4-...

~%

Fenclofenac Structure

3-(Trifluoromethyl)phenol Structure

3-(Trifluoromet...

2-Chlorobenzoic acid Structure

2-Chlorobenzoic acid

~%

2-[3-(Trifluoromethyl)phenoxy]benzoic acid Structure

2-[3-(Trifluoro...

Malonic acid Structure

2-(2,4-DICHLOROPHENOXY)BENZENECARBALDEHYDE Structure

2-(2,4-DICHLORO...

~32%

3-[2-(2,4-Dichlorophenoxy)phenyl]acrylic acid Structure

3-[2-(2,4-Dichl...