Tetrahedron

Furo [3, 2-b] pyridine: a convenient unit for the synthesis of polyheterocycles

A Chartoire, C Comoy, Y Fort

文献索引：Chartoire, Anthony; Comoy, Corinne; Fort, Yves Tetrahedron, 2008 , vol. 64, # 48 p. 10867 - 10873

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被引用次数: 21

摘要

An efficient and rapid synthesis of furo [3, 2-b] pyridine 1 is described using a one-pot Sonogashira coupling/heteroannulation sequence. Regioselective lithiation of this synthon was performed leading to various 2-substituted furo [3, 2-b] pyridines. Some of them were used as substrates for short functional synthesis of polyheterocycles.