Synthesis of Alkaloid Analogues from β??Amino Alcohols by β??Fragmentation of Primary Alkoxyl Radicals

A Boto, D Hernández, R Hernández…

文献索引：Boto, Alicia; Hernandez, Dacil; Hernandez, Rosendo; Montoya, Adriana; Suarez, Ernesto European Journal of Organic Chemistry, 2007 , # 2 p. 325 - 334

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被引用次数: 10

摘要

Abstract The fragmentation of primary alkoxyl radicals is usually a minor process with respect to hydrogen abstraction and other competing reactions. However, when β-amino alcohols were used as substrates, the scission proceeded in good to excellent yields and no side reactions were observed. The fragmentation can be coupled with an allylation or alkylation reaction, to give alkaloid analogues and functionalized nitrogen heterocycles.(© ...