The Journal of organic chemistry

Synthesis of 1-deoxy-D-xylulose and 1-deoxy-D-xylulose-5-phosphate

BSJ Blagg, CD Poulter

文献索引：Blagg, Brian S. J.; Poulter, C. Dale Journal of Organic Chemistry, 1999 , vol. 64, # 5 p. 1508 - 1511

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被引用次数: 39

摘要

1-Deoxy-d-xylulose (4) and the corresponding 5-phosphate (5) are substrates for the first pathway-specific enzymes in the biosynthesis of thiamine diphosphate (vitamin B1), pyridoxol phosphate (vitamin B6), and the nonmevalonate family of isoprenoid compounds recently discovered in bacteria and plant chloroplasts. Both 4 and 5 were synthesized from commercially available (-)-2, 3-O-isopropylidene-d-threitol (10). The protected tetraol was ...