Chemical and enzymatic synthesis of 1-deoxy-D-xylulose-5-phosphate

SV Taylor, LD Vu, TP Begley, U Schörken…

文献索引：Taylor, Sean V.; Vu, Long D.; Begley, Tadhg P. Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2375 - 2377

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被引用次数: 56

摘要

1-Deoxy-D-xylulose-5-phosphate 1 or the corresponding nonphosphorylated sugar, 2, has been identified as a precursor in three major biosynthetic pathways (Scheme 1). In higher plants, algae, and bacteria, a nonmevalonate pathway to isopentenyl diphosphate 3 which utilizes 1 or 2 has been demonstrated. 1 In bacteria, 1 or 2 is involved in the biosynthesis of thiamin pyrophosphate 4. 2 In Escherichia coli, it has been demonstrated that one of the ...