Regioselective synthesis and evaluation of 3-alkylidene-1, 3-dihydroisobenzofurans as potential antidepressant agents

C Praveen, C Iyyappan, K Girija, KS Kumar…

文献索引：Praveen; Iyyappan; Girija; Kumar, K Suresh; Perumal Journal of Chemical Sciences, 2012 , vol. 124, # 2 p. 451 - 462

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被引用次数: 16

摘要

Abstract 3-Alkylidene-1, 3-dihydroisobenzofurans exhibited moderate antidepressant activity as evaluated by forced swim and tail suspension test methods. Virtual screening was carried out by docking the designed compounds into the serotonin binding sites of arabinase protein to predict the analogue binding mode of the compounds to the SSRIs. Graphical Abstract 3-Alkylidene-1, 3-dihydroisobenzofurans exhibited moderate antidepressant ...