Discovery, synthesis and SAR analysis of novel selective small molecule S1P 4-R agonists based on a (2Z, 5Z)-5-((pyrrol-3-yl) methylene)-3-alkyl-2-(alkylimino) …

…, S Velaparthi, M Crisp, P Chase, P Hodder…

文献索引：Urbano, Mariangela; Guerrero, Miguel; Velaparthi, Subash; Crisp, Melissa; Chase, Peter; Hodder, Peter; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, Edward Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 22 p. 6739 - 6745

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被引用次数: 13

摘要

High affinity and selective S1P4 receptor (S1P4-R) small molecule agonists may be important proof-of-principle tools used to clarify the receptor biological function and effects to assess the therapeutic potential of the S1P4-R in diverse disease areas including treatment of viral infections and thrombocytopenia. A high-throughput screening campaign of the Molecular Libraries-Small Molecule Repository was carried out by our laboratories and ...