European Journal of Organic Chemistry

Stereoselective Organocatalytic Approach to α, β??Disubstituted?螃漫?amino Acids: A Short Enantioselective Synthesis of Cispentacin

A Pou, A Moyano

文献索引：Pou, Ana; Moyano, Albert European Journal of Organic Chemistry, 2013 , # 15 p. 3103 - 3111

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被引用次数: 10

摘要

Abstract α-Branched α, β-unsaturated aldehydes have been tested in the organocatalytic tandem Michael addition/cyclization with N-(benzyloxycarbonyl) hydroxylamine, a reaction which until now has been restricted to α-unsubstituted enals. Starting from cyclopentene-2- carbaldehyde, and using diphenylprolinol trimethylsilyl ether as a chiral amine catalyst, this approach has led to the development of a practical, high yielding (93–98% overall yield, ...