Structure–activity relationship studies of 1-(4-chloro-2, 5-dimethoxyphenyl)-3-(3-propoxypropyl) thiourea, a non-nucleoside reverse transcriptase inhibitor of human …

M Weitman, K Lerman, A Nudelman, DT Major…

文献索引：Weitman, Michal; Lerman, Keti; Nudelman, Abraham; Major, Dan Thomas; Hizi, Amnon; Herschhorn, Alon European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 447 - 467

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被引用次数: 9

摘要

The reverse transcriptase (RT) of the human immunodeficiency virus type-1 (HIV-1) is still a prime target for drug development due to the continuing need to block drug-resistant RT mutants by new inhibitors. We have previously identified 1-(4-chloro-2, 5-dimethoxyphenyl)- 3-(3-propoxypropyl) thiourea, compound 1, as a potent RT inhibitor from an available chemical library. Here, we further modified this compound to study structure–activity ...