Direct asymmetric intermolecular aldol reactions catalyzed by amino acids and small peptides

…, W Zou, P Dziedzic, I Ibrahem, E Reyes…

文献索引：Cordova, Armando; Zou, Weibiao; Dziedzic, Pawel; Ibrahem, Ismail; Reyes, Efraim; Xu, Yongmei Chemistry - A European Journal, 2006 , vol. 12, # 20 p. 5383 - 5397

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被引用次数: 223

摘要

Abstract In nature there are at least nineteen different acyclic amino acids that act as the building blocks of polypeptides and proteins with different functions. Here we report that α- amino acids, β-amino acids, and chiral amines containing primary amine functions catalyze direct asymmetric intermolecular aldol reactions with high enantioselectivities. Moreover, the amino acids can be combined into highly modular natural and unusual small peptides that ...