Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening

E Procházková, P Jansa, A Březinová…

文献索引：Prochazkova, Eliska; Jansa, Petr; Brezinova, Anna; Cechova, Lucie; Mertlikova-Kaiserova, Helena; Holy, Antonin; Dracinsky, Martin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 20 p. 6405 - 6409

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被引用次数: 4

摘要

The oxidation reactions of 5-aminopyrimidine derivatives in dimethyl sulphoxide (DMSO) were studied. The DMSO solutions of the studied compounds became deeply coloured within a few hours or days. The oxidation products can undergo further condensation reactions with the starting pyrimidines to yield bipyrimidines and/or pyrimidopteridines. The reaction mechanism of the oxidation-condensation reaction was also supported by ...