The Wittig–Horner reaction for the synthesis of neratinib

N Gu, J Yang, P Wang, L Li, Y Chen, M Ji

文献索引：Gu, Ning; Yang, Jiabin; Wang, Peng; Li, Lushen; Chen, Yang; Ji, Min Research on Chemical Intermediates, 2013 , vol. 39, # 7 p. 3105 - 3110

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被引用次数: 1

摘要

Abstract The Wittig–Horner reaction is a classic method to get alkenes by reaction phosphonates with carbonyl compounds. In this study, it was used for the synthesis of the anticancer drug neratinib. In this method, ethyl diethoxyphosphinylacetate and dimethylaminoacetaldehyde diethylacetal, replacing (E)-4-(dimethylamino) but-2-enoyl acid hydrochloride and oxalyl chloride, were used to synthesize the 6-position side chain of ...