Design and Discovery of 6-[(3 S, 4 S)-4-Methyl-1-(pyrimidin-2-ylmethyl) pyrrolidin-3-yl]-1-(tetrahydro-2 H-pyran-4-yl)-1, 5-dihydro-4 H-pyrazolo [3, 4-d] pyrimidin-4-one …

PR Verhoest, KR Fonseca, X Hou…

文献索引：Journal of Medicinal Chemistry, , vol. 55, # 21 p. 9045 - 9054

全文：HTML全文

被引用次数: 29

摘要

... Journal of Medicinal ... We have previously described the utilization of parallel medicinal chemistry to enable the potential synthesis of thousands of pyrazolopyrimidines ... Our strategy to improve the pharmacokinetics of our lead molecule 2 again utilized parallel chemistry to target ...