e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Design and Discovery of 6-[(3 S, 4 S)-4-Methyl-1-(pyrimidin-2-ylmethyl) pyrrolidin-3-yl]-1-(tetrahydro-2 H-pyran-4-yl)-1, 5-dihydro-4 H-pyrazolo [3, 4-d] pyrimidin-4-one …

PR Verhoest, KR Fonseca, X Hou…

Index: Journal of Medicinal Chemistry, , vol. 55, # 21 p. 9045 - 9054

Full Text: HTML

Citation Number: 29

Abstract

... Journal of Medicinal ... We have previously described the utilization of parallel medicinal chemistry to enable the potential synthesis of thousands of pyrazolopyrimidines ... Our strategy to improve the pharmacokinetics of our lead molecule 2 again utilized parallel chemistry to target ...

Tetrahydro-2H-pyran-4-one Structure

Tetrahydro-2H-p...

~%

5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide Structure

5-Amino-1-(tetr...

1-Boc-2-(4-tetrahydropyranyl)hydrazine Structure

1-Boc-2-(4-tetr...

~%

5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide Structure

5-Amino-1-(tetr...

Tetrahydro-2H-pyran-4-one Structure

Tetrahydro-2H-p...

~%

5-AMino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carbonitrile Structure

5-AMino-1-(tetr...

1-Boc-2-(4-tetrahydropyranyl)hydrazine Structure

1-Boc-2-(4-tetr...

~%

5-AMino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carbonitrile Structure

5-AMino-1-(tetr...

Design and Discovery of 6-[(3 S, 4 S)-4-Methyl-1-(pyrimidin-...

[Verhoest, Patrick R.; Fonseca, Kari R.; Hou, Xinjun; Proulx-Lafrance, Caroline; Corman, Michael; Helal, Christopher J.; Claffey, Michelle M.; Tuttle, Jamison B.; Coffman, Karen J.; Liu, Shenpinq; Nelson, Frederick; Kleiman, Robin J.; Menniti, Frank S.; Schmidt, Christopher J.; Vanase-Frawley, Michelle; Liras, Spiros Journal of Medicinal Chemistry, 2012 , vol. 55, # 21 p. 9045 - 9054]