Chemical Communications

Kinetic resolution of trans-cycloalkane-1, 2-diols via Steglich esterification

R Hrdina, CE Müller, PR Schreiner

文献索引：Hrdina, Radim; Mueller, Christian E.; Schreiner, Peter R. Chemical Communications, 2010 , vol. 46, # 15 p. 2689 - 2690

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被引用次数: 32

摘要

Esterification is one of the key reactions that ubiquitously appear both in nature and in organic synthesis. 1 While biosynthetic ester formation generally proceeds through a mixed anhydride consisting of the transferred acyl function and ATP, 2 the chemist's often employed variant is the Steglich esterification using acids and carbodiimides in the presence of 4-dimethylaminopyridine (DMAP) as a nucleophilic catalyst. 3 This reaction is viewed as proceeding through an O- ...