Total Synthesis of Branimycin: An Evolutionary Approach

…, W Felzmann, A Gromov, S Marchart…

文献索引：Enev, Valentin S.; Felzmann, Wolfgang; Gromov, Alexey; Marchart, Stefan; Mulzer, Johann Chemistry - A European Journal, 2012 , vol. 18, # 31 p. 9651 - 9668

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被引用次数: 10

摘要

Abstract The first total synthesis of the macrolactone antibiotic branimycin (4) has been described. The key disconnection leads to a cis-dehydrodecalone core and a polyketide side chain which are connected via organometallic addition. The dehydrodecalone core was targeted via altogether five different approaches featuring various kinds of chiral elements and ring-closing methodology. In the end the most successful method starting from ...