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Synthesis of 2-substituted trifluoromethylquinolines for the evaluation of leishmanicidal activity.

J Dade, O Provot, H Moskowitz, J Mayrargue…

文献索引:Dade; Provot; Moskowitz; Mayrargue; Prina Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 4 p. 480 - 483

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被引用次数: 38

摘要

Leishmaniasis are a group of diseases with different clini- cal manifestations (cutaneous, mucocutaneous and visceral), which represent a severe public health problem in some trop- ical and subtropical areas. They are often disfiguring and sometimes fatal protozoan diseases affecting over 12 million people worldwide and, for which, there is still no effective vaccine. Chemotherapy remains the most effective control measure for leishmaniasis. However, current drugs, like sodium sti- ...