Synthesis of 2-substituted trifluoromethylquinolines for the evaluation of leishmanicidal activity.

J Dade, O Provot, H Moskowitz, J Mayrargue…

Index: Dade; Provot; Moskowitz; Mayrargue; Prina Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 4 p. 480 - 483

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Citation Number: 38

Abstract

Leishmaniasis are a group of diseases with different clini- cal manifestations (cutaneous, mucocutaneous and visceral), which represent a severe public health problem in some trop- ical and subtropical areas. They are often disfiguring and sometimes fatal protozoan diseases affecting over 12 million people worldwide and, for which, there is still no effective vaccine. Chemotherapy remains the most effective control measure for leishmaniasis. However, current drugs, like sodium sti- ...