Natural product reports

Asymmetric organocatalysis in total synthesis–a trial by fire

E Marqués-López, RP Herrera, M Christmann

文献索引：Yakugaku Zasshi, , vol. 67, p. 141 Chem.Abstr., , p. 9539

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被引用次数: 153

摘要

... The first step of the synthesis uses an organocatalytic Michael 41 addition of aldehyde 67 to the nitroalkene 68, catalyzed by diphenylprolinol silyl ether 58 (5 mol ... Thus, treatment of the (5S)-71/(5R)-71 mixture with p-toluenethiol in the presence of Cs 2 CO 3 gave the Michael ...