Natural product reports

Asymmetric organocatalysis in total synthesis–a trial by fire

E Marqués-López, RP Herrera, M Christmann

Index: Yakugaku Zasshi, , vol. 67, p. 141 Chem.Abstr., , p. 9539

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Citation Number: 153

Abstract

... The first step of the synthesis uses an organocatalytic Michael 41 addition of aldehyde 67 to the nitroalkene 68, catalyzed by diphenylprolinol silyl ether 58 (5 mol ... Thus, treatment of the (5S)-71/(5R)-71 mixture with p-toluenethiol in the presence of Cs 2 CO 3 gave the Michael ...