Synthetic Scheme for the Preparation of 13C??Labeled 3, 4??Didehydro??Retinal, 3??Hydroxyretinal, and 4??Hydroxyretinal up to Uniform 13C??Enrichment

…, MB van de Weerd, J Lugtenburg

文献索引：Van Wijk, Arjan A. C.; Van de Weerd, Michiel B.; Lugtenburg, Johan European Journal of Organic Chemistry, 2003 , # 5 p. 863 - 868

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被引用次数: 7

摘要

Abstract A modular synthetic scheme has been developed for the synthesis of 13 C-labeled naturally occurring visual pigment chromophores; 3, 4-didehydroretinal, 3-hydroxyretinal, and 4-hydroxyretinal. These compounds can now be made with> 99% 13 C enrichment at any position or combination of positions. We used the common C 10+ C 5+ C 5 scheme for the synthesis of retinals, and by making variations in the C 10 part we can now prepare ...