Thyroid hormone uptake by hepatocytes: structure-activity relationships of phenylanthranilic acids with inhibitory activity

DK Chalmers, GH Scholz, DJ Topliss…

文献索引：Chalmers; Scholz; Topliss; Kolliniatis; Munro; Craik; Iskander; Stockigt Journal of Medicinal Chemistry, 1993 , vol. 36, # 9 p. 1272 - 1277

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被引用次数: 33

摘要

The synthesis of a series of mono-and disubstituted N-phenylanthranilic acids is described. Substituents on the phenyl ring include C1, CN, OH, CF3, Br, I, CH3, OCH3, and OCFZCFZH. These compounds have been tested for their inhibitory effect on triiodothyronine (T3) uptake by H4 hepatocytes. The nonsteroidal antiinflammatory drugs flufenamic acid, mefenamic acid, and meclofenamic acid and the structurally related ...