Synthesis of optically active arylglycines by photolysis of optically active (. beta.-hydroxyamino) carbene-chromium (0) complexes

JM Vernier, LS Hegedus, DB Miller

文献索引：Vernier, Jean-Michel; Hegedus, Louis S.; Miller, David B. Journal of Organic Chemistry, 1992 , vol. 57, # 25 p. 6914 - 6920

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被引用次数: 41

摘要

Although arylglycines are nonproteinogenic amino acids, they me found in a number of important biologically active compounds, including the vancomycins,'amoxicillins, 2 nocardicina? and cephalecina.'The asymmetric synthesie of this class of compounds6 ie complicated by the lability of the a-proton, and syntheses involving basic conditions are compromised by attendant racemization. Because of