Identification of a chemical tool for the orphan nuclear receptor FXR

…, AM Fivush, G Chandra, KD Plunket…

文献索引：Maloney; Parks; Haffner; Fivush; Chandra; Plunket; Creech; Moore; Wilson; Lewis; Jones; Willson Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 2971 - 2974

全文：HTML全文

被引用次数: 382

摘要

Bile acids are the amphipathic terminal metabolites of hepatic cholesterol metabolism. In humans, cholic acid and chenodeoxycholic acid (CDCA; Chart 1) are the primary bile acids found in the enterohepatic circulation. These bile acids play important roles in the regulation of intestinal lipid absorption, bile flow, and biliary lipid secretion. 1, 2 Bile acids are synthesized in the liver and secreted into the intestine, where their physical properties ...