Identification of a chemical tool for the orphan nuclear receptor FXR

…, AM Fivush, G Chandra, KD Plunket…

Index: Maloney; Parks; Haffner; Fivush; Chandra; Plunket; Creech; Moore; Wilson; Lewis; Jones; Willson Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 2971 - 2974

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Citation Number: 382

Abstract

Bile acids are the amphipathic terminal metabolites of hepatic cholesterol metabolism. In humans, cholic acid and chenodeoxycholic acid (CDCA; Chart 1) are the primary bile acids found in the enterohepatic circulation. These bile acids play important roles in the regulation of intestinal lipid absorption, bile flow, and biliary lipid secretion. 1, 2 Bile acids are synthesized in the liver and secreted into the intestine, where their physical properties ...