Tetrahedron: Asymmetry

N-Benzyl-norephedrine derivatives as new, efficient ligands for ruthenium-catalyzed asymmetric transfer hydrogenation of functionalized ketones

K Everaere, JF Carpentier, A Mortreux…

文献索引：Everaere, Kathelyne; Carpentier, Jean-Francois; Mortreux, Andre; Bulliard, Michel Tetrahedron Asymmetry, 1999 , vol. 10, # 21 p. 4083 - 4086

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被引用次数: 30

摘要

Significant catalytic activities (up to 600 h− 1 at 20° C) and enantiomeric excesses ranging from 56 to 89% for the asymmetric transfer hydrogenation of β-ketoesters, methoxyacetone and 2-acetylpyridine to the corresponding alcohols are achieved in the presence of catalytic combinations of [RuCl2 (η6-arene)] 2 and N-substituted derivatives of (1S, 2R)- norephedrine such as N-benzyl-norephedrine and N-(4-biphenyl) methyl-norephedrine.