Convergent, kilogram scale synthesis of an Akt kinase inhibitor

P Grongsaard, PG Bulger, DJ Wallace…

文献索引：Organic Process Research and Development, , vol. 16, # 5 p. 1069 - 1081

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被引用次数: 18

摘要

... To demonstrate proof-of-principle for this process, a preparative scale run was perfomed using the ... After workup, the organic layer from the 1 kg flow run was combined with both 5 ... used phenylacetyl chloride and DBU in THF at 100 °C.(6) An alternative procedure was developed ...