Convergent, kilogram scale synthesis of an Akt kinase inhibitor

P Grongsaard, PG Bulger, DJ Wallace…

Index: Organic Process Research and Development, , vol. 16, # 5 p. 1069 - 1081

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Citation Number: 18

Abstract

... To demonstrate proof-of-principle for this process, a preparative scale run was perfomed using the ... After workup, the organic layer from the 1 kg flow run was combined with both 5 ... used phenylacetyl chloride and DBU in THF at 100 °C.(6) An alternative procedure was developed ...

Convergent, kilogram scale synthesis of an Akt kinase inhibi...

[Grongsaard, Pintipa; Bulger, Paul G.; Wallace, Debra J.; Tan, Lushi; Chen, Qinghao; Dolman, Sarah J.; Nyrop, Jason; Hoerrner, R. Scott; Weisel, Mark; Arredondo, Juan; Itoh, Takahiro; Xie, Chengfu; Wen, Xianghui; Zhao, Dalian; Muzzio, Daniel J.; Bassan, Ephraim M.; Shultz, C. Scott Organic Process Research and Development, 2012 , vol. 16, # 5 p. 1069 - 1081]