Mn-Catalyzed Three-Component Reactions of Imines/Nitriles, Grignard Reagents, and Tetrahydrofuran: An Expedient Access to 1, 5-Amino/Keto Alcohols

…, H Chen, ZT Huang, QY Zheng, C Wang

文献索引：He, Ruoyu; Jin, Xiqing; Chen, Hui; Huang, Zhi-Tang; Zheng, Qi-Yu; Wang, Congyang Journal of the American Chemical Society, 2014 , vol. 136, # 18 p. 6558 - 6561

全文：HTML全文

被引用次数: 18

摘要

An expedient Mn-catalyzed three-component synthesis of 1, 5-amino/keto alcohols from Grignard reagents, imines/nitriles, and tetrahydrofuran (THF) is described, which deviates from the classic Grignard addition to imines/nitriles in THF solvent. THF is split and “sewn” in an unprecedented manner in the reaction, leading to the formation of two geminal C–C bonds via C–H and C–O cleavage. Mechanistic experiments and DFT calculations reveal ...