Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action

…, MVN de Souza, RA Siqueira, NC Romeiro…

文献索引：Costa, Jorge C.S.; Neves, Josiane S.; de Souza, Marcus V.N.; Siqueira, Rodrigo A.; Romeiro, Nelilma C.; Boechat, Nubia; Silva, Patricia M.R.e; Martins, Marco A. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 1162 - 1166

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被引用次数: 13

摘要

The present structure-activity relationship (SAR) study focused on chemical modifications of the structure of the local anesthetic lidocaine, and indicated analogues having reduced anesthetic potency, but with superior potency relative to the prototype in preventing anaphylactic or histamine-evoked ileum contraction. From the SAR analysis, 2- (diethylamino)-N-(trifluoromethyl-phenyl) and 2-(diethylamino)-N-(dimethyl-phenyl) ...