Synthesis, biological testing, and stereochemical assignment of an end group modified retro-inverso bombesin C-terminal nonapeptide

M Cushman, J Jurayj, JD Moyer

文献索引：Cushman, Mark; Jurayj, Jurjus; Moyer, James D. Journal of Organic Chemistry, 1990 , vol. 55, # 10 p. 3186 - 3194

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被引用次数: 27

摘要

The end group modified retro-inverso bombesin C-terminal nonapeptide 3 and its diastereomer 4 have been synthesized. The absolute configurations at the substituted malonamic acid residues in 3 and 4 were determined by chemical correlation with D-and L-2- aminobutyric acids of known absolute configuration. Thus, the absolute configurations at the substituted malonamic acid residues in each diastereomer of 25a were determined by ...