Tetrahedron letters

A new solvent system for efficient synthesis of 1, 2, 3-triazoles

BY Lee, SR Park, HB Jeon, KS Kim

文献索引：Lee, Bo-Young; Park, So Ra; Jeon, Heung Bae; Kim, Kwan Soo Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5105 - 5109

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被引用次数: 159

摘要

The use of CH2Cl2 as a co-solvent with H2O in the copper (I)-catalyzed 1, 3-dipolar cycloaddition of organic azides and alkynes increased reaction rates and provided the corresponding 1, 2, 3-triazoles in excellent yields compared to other organic co-solvent systems. Moreover, we applied this discovery to prepare the functional multivalent compound in an excellent yield.