Tetrahedron letters

A new solvent system for efficient synthesis of 1, 2, 3-triazoles

BY Lee, SR Park, HB Jeon, KS Kim

Index: Lee, Bo-Young; Park, So Ra; Jeon, Heung Bae; Kim, Kwan Soo Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5105 - 5109

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Citation Number: 159

Abstract

The use of CH2Cl2 as a co-solvent with H2O in the copper (I)-catalyzed 1, 3-dipolar cycloaddition of organic azides and alkynes increased reaction rates and provided the corresponding 1, 2, 3-triazoles in excellent yields compared to other organic co-solvent systems. Moreover, we applied this discovery to prepare the functional multivalent compound in an excellent yield.

~92%

Study on affinity profile toward native human and bovine ade...

[Biagi; Livi; da Settimo; Lucacchini; Mazzoni; Barili Farmaco, Edizione Scientifica, 1985 , vol. 40, # 2 p. 73 - 85]

Solid-phase synthesis of functionalized 1, 2, 3-triazoles

[Blass, Benjamin E; Coburn, Keith R; Faulkner, Amy L; Hunn, Cheryl L; Natchus, Michael G; Parker, M.Sharon; Portlock, David E; Tullis, Joshua S; Wood, Richard Tetrahedron Letters, 2002 , vol. 43, # 22 p. 4059 - 4061]