First multigram preparation of SCP-123, a novel water-soluble analgesic

L Miao, L Xu, KW Narducy…

文献索引：Miao, Lei; Xu, Liang; Narducy, Kenneth W.; Trudell, Mark L. Organic Process Research and Development, 2009 , vol. 13, # 4 p. 820 - 822

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被引用次数: 7

摘要

A short multigram process for the preparation of the analgesic compound SCP-123 (4) and its sodium salt has been developed. ... The recent discovery that the analgesic properties of the saccharin derivative of acetaminophen, SCP-1 (3), possess a potency equal to that of the properties of acetaminophen, with significantly diminished hepatotoxicity, has prompted an extensive investigation into this class of compounds as a new generation of analgesic drugs.(8-12) The lead ...