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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis and biological evaluation of 2-fluoro-8-azaadenosine and related compounds

JA Montgomery, AT Shortnacy…

文献索引：Montgomery, John A.; Shortnacy, Anita T.; Secrist, John A. Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1483 - 1489

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被引用次数: 33

摘要

Throughout the text we have utilized the 8-azapurine designation to more readily relate the compounds discussed to the corresponding purines. The Experimental Section has the correct names for the compounds synthesized. Proper names for other compounds mentioned in the text are as follows: 2, 6-bis (rnethylthio)-8-aza-SH-purine, 5, 7-bis (methylthio)-3H-1, 2, 3-triazolo [4, 5-d] pyrimidine; 8-azaadenosine, 3-PD-ribo-furanosyl- ...

8-Azaadenosine结构式

丙酮结构式

~%

3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,3-[2,3-O-(1-methylethylidene)-b-D-ribofuranosyl]-结构式

3H-1,2,3-Triazo...

5,7-Diamino-1H-1,2,3-triazolo[4,5-d]pyrimidine结构式

5,7-Diamino-1H-...

~19%

3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,5-fluoro-结构式

3H-1,2,3-Triazo...

5,7-bis(methylsulfanyl)-2H-triazolo[4,5-d]pyrimidine结构式

5,7-bis(methyls...

四乙酰核糖结构式

四乙酰核糖

~%

2-(5-amino-3-methylsulfonyl-2,4,7,8,9-pentazabicyclo[4.3.0]nona-2,4,6,9-tetraen-8-yl)-5-(hydroxymethyl)oxolane-3,4-diol结构式

2-(5-amino-3-me...

3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,5-(methylsulfonyl)-3-b-D-ribofuranosyl-结构式

3H-1,2,3-Triazo...

3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,5-(methylsulfonyl)-3-b-D-ribofuranosyl-结构式

3H-1,2,3-Triazo...

~82%

2-(3,5-diamino-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol结构式

2-(3,5-diamino-...

(2R,3R,4S,5R)-2-(7-amino-5-ethoxy-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol结构式

(2R,3R,4S,5R)-2...

乙醇结构式

3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,5-(methylsulfonyl)-3-b-D-ribofuranosyl-结构式

3H-1,2,3-Triazo...

~85%

2-(3,5-diamino-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol结构式

2-(3,5-diamino-...

(2R,3R,4S,5R)-2-(7-amino-5-ethoxy-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol结构式

(2R,3R,4S,5R)-2...

四乙酰核糖结构式

四乙酰核糖

~%

2-(3,5-diamino-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol结构式

2-(3,5-diamino-...

2-(3,5-diamino-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol结构式

2-(3,5-diamino-...

~20%

2-(5-amino-3-fluoro-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol结构式

2-(5-amino-3-fl...

四乙酰核糖结构式

四乙酰核糖

~%

2-(5-amino-3-fluoro-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol结构式

2-(5-amino-3-fl...

3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,5-(methylsulfonyl)-3-b-D-ribofuranosyl-结构式

3H-1,2,3-Triazo...

~%

2-(5-amino-3-fluoro-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol结构式

2-(5-amino-3-fl...

四乙酰核糖结构式

四乙酰核糖

~%

3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,5-(methylsulfonyl)-3-b-D-ribofuranosyl-结构式

3H-1,2,3-Triazo...

5,7-bis(methylsulfanyl)-2H-triazolo[4,5-d]pyrimidine结构式

5,7-bis(methyls...

四乙酰核糖结构式

四乙酰核糖

~%

2-(5-amino-3-methylsulfonyl-2,4,7,8,9-pentazabicyclo[4.3.0]nona-2,4,6,9-tetraen-8-yl)-5-(hydroxymethyl)oxolane-3,4-diol结构式

2-(5-amino-3-me...

3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,5-(methylsulfonyl)-3-b-D-ribofuranosyl-结构式

3H-1,2,3-Triazo...