Carbonic anhydrase inhibitors-Part 49: Synthesis of substituted ureido and thioureido derivatives of aromatic/heterocyclic sulfonamides with increased affinities for …

CT Supuran, A Scozzafava, BC Jurca…

文献索引：Supuran, Claudiu T.; Scozzafava, Andrea; Jurca, Bogdan C.; Ilies, Marc A. European Journal of Medicinal Chemistry, 1998 , vol. 33, # 2 p. 83 - 93

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被引用次数: 133

摘要

Reaction of nine aromatic/heterocyclic sulfonamides containing a free amino group with aryl isocyanates/isothiocyanates or allyl isothiocyanate afforded the corresponding urea/thiourea derivatives, which were characterized by standard physico-chemical procedures and assayed as inhibitors of three isozymes of carbonic anhydrase (CA), ie hCA I, hCA II and bCA IV (h= human, b= bovine isozyme). Another series of compounds, 1, 5-disubstituted-2 ...