QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds

…, PC Jurs, C Morisseau, BD Hammock

文献索引：McElroy, Nathan R.; Jurs, Peter C.; Morisseau, Christophe; Hammock, Bruce D. Journal of Medicinal Chemistry, 2003 , vol. 46, # 6 p. 1066 - 1080

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被引用次数: 63

摘要

A data set of 348 urea-like compounds that inhibit the soluble epoxide hydrolase enzyme in mice and humans is examined. Compounds having IC50 values ranging from 0.06 to> 500 μM (murine) and 0.10 to> 500 μM (human) are categorized as active or inactive for classification, while quantitation is performed on smaller compound subsets ranging from 0.07 to 431 μM (murine) and 0.11 to 490 μM (human). Each compound is represented by ...