A series of compounds structurally related to the carcinogen and mutagen 5-methylchrysene (1) was synthesized and tested for mutagenicity toward S. typhimurium TA 100. The compounds prepared were 5, ll-dimethylchrysene (2), 5-(hydroxymethy1) chrysene (31, 5- (acetoxymethy1) chrysene (4), 5-carbomethoxychrysene (5), 5-(hydroxy-methyl)-1, 2, 3, 4- tetrahydrochrysene (6), 5-carbomethoxy-1, 2, 3, 4-tetrahydrochrysene (7), and 5H- ...
