A study of chemical carcinogenesis. 19. Synthesis and mutagenicity of 5, 11-dimethylchrysene and some methyl-oxidized derivatives of 5-methylchrysene

S Amin, SS Hecht, E LaVoie…

Index: Amin,S. et al. Journal of Medicinal Chemistry, 1979 , vol. 22, # 11 p. 1336 - 1340

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Citation Number: 21

Abstract

A series of compounds structurally related to the carcinogen and mutagen 5-methylchrysene (1) was synthesized and tested for mutagenicity toward S. typhimurium TA 100. The compounds prepared were 5, ll-dimethylchrysene (2), 5-(hydroxymethy1) chrysene (31, 5- (acetoxymethy1) chrysene (4), 5-carbomethoxychrysene (5), 5-(hydroxy-methyl)-1, 2, 3, 4- tetrahydrochrysene (6), 5-carbomethoxy-1, 2, 3, 4-tetrahydrochrysene (7), and 5H- ...