In spite of the considerable success of the hypnotics of the acetamide, acyl urea, and barbituric acid types, a need still exists for less toxic compounds with hypnotic properties. The structural features which appear to account for the pharmacological action of the above- mentioned compounds are two: one or more-CONH-groups, and branched-chain alkyl groups whose function is apparently to confer high lipoid-solubility on the molecules of ...
