Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate

…, ET Powers, IA Wilson, JW Kelly

文献索引：Johnson, Steven M.; Connelly, Stephen; Wilson, Ian A.; Kelly, Jeffery W. Journal of Medicinal Chemistry, 2008 , vol. 51, # 20 p. 6348 - 6358

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被引用次数: 28

摘要

Molecules that bind selectively to a given protein and then undergo a rapid chemoselective reaction to form a covalent conjugate have utility in drug development. Herein a library of 1, 3, 4-oxadiazoles substituted at the 2 position with an aryl sulfonyl fluoride and at the 5