Synthesis of cationic metalloporphyrin precursors related to the design of DNA cleavers

C Casas, B Saint-Jalmes, C Loup…

文献索引：Casas, Christiane; Saint-Jalmes, Bernadette; Loup, Christophe; Lacey, C. Jeffrey; Meunier, Bernard Journal of Organic Chemistry, 1993 , vol. 58, # 10 p. 2913 - 2917

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被引用次数: 61

摘要

The design of specific DNA cleavers is a growing field of research for several reasons:(i) DNA is the biological target of a large number of antitumor agents which are able to cleave double-stranded nucleic acids, bleomycin,'neocarzinostatin, 2 and enediyne molecules, 3 (ii) transition metal complexes linked to a DNA recognizing molecule (intercalating agentst peptides: or oligonucleotides6) are also able to cleave selectively single-or double- ...