The design of specific DNA cleavers is a growing field of research for several reasons:(i) DNA is the biological target of a large number of antitumor agents which are able to cleave double-stranded nucleic acids, bleomycin,'neocarzinostatin, 2 and enediyne molecules, 3 (ii) transition metal complexes linked to a DNA recognizing molecule (intercalating agentst peptides: or oligonucleotides6) are also able to cleave selectively single-or double- ...
